Umubare wa Cas: 146-56-5 Inzira ya molekulari: C20H21ClN2O4
| Ingingo yo gushonga | 176-178 ° C. |
| Ubucucike | 1.02 g / cm³ |
| ububiko bwa temp | yashwanyaguritse ku cyumba cy'ubushyuhe, hanze y'izuba ryinshi kandi ahantu h'ubushuhe |
| gukemura | 50 mg / ml (Muri Ethanol);Kudashonga mumazi |
| ibikorwa byiza | Impamyabumenyi +111,6 (C = 1, methanol) |
| Kugaragara | ifu yera cyangwa hafi yera ifu ya kristaline |
| Isuku | ≥97% |
ni "dihydropyridine calcium antagonist" (calcium antagonist, cyangwa umuyoboro uhagarika umuyoboro) ibuza kugenda kwa "calcium ion" yerekeza mu ngirangingo z'imitsi yoroheje na myocytes z'umutima.Ubushakashatsi bwakozwe bwerekana ko bujyanye n "imbuga zihuza" kuri "dihydropyridine" na "non-dihydropyridines".Byombi umutima n'umutima byoroshye imitsi 'inzira zandura' biterwa no kwinjiza 'calcium ion idasanzwe' muri selile binyuze mumiyoboro yihariye ya ion.guhitamo kubuza gutembera kwa calcium ion muri utwo tugingo ngengabuzima, uburyo bugira ingaruka ku ngirabuzimafatizo zoroheje ziva mu mitsi kurusha selile z'umutima.Ingaruka mbi ya inotropique (Inotrope), cyangwa kugabanuka kwa myocardial kwandura, irashobora kugaragara muri vitro.Nyamara, ingaruka nkizo ntizigeze zigaragara mu nyamaswa zitangwa mugihe cyagenwe cyo kuvura.Imyunyungugu ya calcium ya calcium ntabwo iterwa na.Mu rwego rwa physiologique pH, ni ionisiyoneri (pKa = 8.6) imikoranire yabyo na calcium ya reseptor ya calcium irangwa nigipimo kigenda gitera imbere cyakira reseptor ihuza urubuga hamwe no gutandukana, kandi ubu buryo bwikigereranyo butera intambwe igenda itangira.
ni vasodilator ya arterial periferique ikora ku buryo butaziguye ku mitsi yoroshye y'amaraso, bikaviramo kugabanuka kw'imitsi iva mu mitsi no kugabanuka k'umuvuduko w'amaraso.Uburyo nyabwo bwo kugabanya angina ntabwo bwumvikana neza, ariko bikekwa ko bukubiyemo ibi bikurikira: Angina Exertional: Ku barwayi bafite angina idasanzwe, NORVASC igabanya ubukana bwa periferique (nyuma yuburemere) mugihe cyakazi cyumutima kurwego urwo arirwo rwose rwimyitozo ngororamubiri kandi bigabanya igipimo ibicuruzwa byumuvuduko, bityo bikagabanya okisijeni ya myocardial.
Mubanze 5mg rimwe kumunsi, kwiyongera kugeza kuri 10mg inshuro imwe kumunsi.
