Orlistat Cas numero: 132539-06-1 Inzira ya molekulari: C28H29NO
| Ingingo yo gushonga | 195-200 ° C. |
| Ubucucike | 1.4 g / cm³ |
| ububiko bwa temp | 2-8 ℃ |
| gukemura | kudashonga mumazi, gushonga gato muri Ethanol, gushonga byoroshye muri chloroform na methanol |
| ibikorwa byiza | +71.6 (c = 1.0, Ethanol) |
| Kugaragara | ifu yera cyangwa idafite umweru ifu ya kristaline |
Olistat ni ndende ya gastrointestinal lipase inhibitor ishobora kwirinda hydrolysis ya triglyceride yinjira mumavuta acide yubusa na monoacylglycerol, ikababuza kwinjizwa, bityo bikagabanya gufata kalori no kugenzura ibiro.Iyo ikoreshejwe nk'imiti irenze imiti yo kwivuza wenyine, orlistat irakwiriye kuvura abarwayi bafite umubyibuho ukabije cyangwa ufite ibiro byinshi (hamwe n'umubare rusange w'umubiri wa ≥ 24 hamwe no kubara hafi y'ibiro / uburebure 2).
Orlistat nibiyobyabwenge bigabanya ibiro, bigurishwa nka Xenical.
Olistat ni inkomoko yuzuye ya lipstatine.Lipstatin ni ingirakamaro ya pancrelipase inhibitor itandukanijwe na Streptomyces toxitricini Ikora cyane cyane mumitsi yigifu.Irashobora kubuza imisemburo ikenerwa na gastrointestinal tract kugirango igogore ibinure, harimo ester pancreatic ester na gastric ester, kandi igabanye kwinjiza ester gastrointestinal ester kugirango ibashe kugabanya ibiro, ariko iracyakeneye guhuzwa nimyitozo ngororamubiri nimirire kugirango igabanye ibiro.
Igipimo cyasabwe kuri Olistat capsules ni 0,12g capsules yafashwe hamwe nifunguro cyangwa mugihe cyisaha imwe nyuma yo kurya.Niba hari ifunguro ritariye cyangwa niba ibiryo bitarimo ibinure, imiti imwe irashobora kuvaho.Ingaruka zo kuvura zo gukoresha igihe kirekire cya orlistat capsules, harimo kugenzura ibiro no kunoza ibintu bishobora guteza ingaruka, birashobora gukomeza.Indyo yumurwayi igomba guhuzwa nimirire, hamwe na karori nkeya.Hafi ya 30% ya calorie ifata ibinure, kandi ibiryo bigomba kuba bikungahaye ku mbuto n'imboga.
