Umubare wa Cas: 330784-47-9 Imiterere ya molekulari ： C23H26ClN7O3 Ishusho Yerekanwe

Umubare numero: 330784-47-9 Imiterere ya molekulari ： C23H26ClN7O3

Ibisobanuro bigufi:

Numero ya Cas: 330784-47-9

Izina ryimiti ：

Inzira ya molekulari ： C23H26ClN7O3

Synonyme ： (S) -2- (2-Hydroxymethyl-1-pyrrolidinyl) -4- (3-chloro-4-mikorerexybenzylamino) -5 - [(2-pyrimidinylmethyl) karbamoyl] pyrimidine

4 - [(3-Chloro-4-mikorobexybenzyl) amino] -2-

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Ibicuruzwa birambuye

Ibicuruzwa

Ibicuruzwa byihariye

Ingingo yo gushonga	150-152 ° C.
Ubucucike	1.372
ububiko bwa temp	Ikidodo cyumye, Ubike muri firigo, munsi ya -20 ° C.
gukemura	DMSO (Buhoro), Methanol (Buhoro, Bishyushye)
ibikorwa byiza	N / A.
Kugaragara	Umweru Kuri Off-White
Isuku	≥98%

farumasi

.bivugwa ko aribwo buryo bwiza bwa PDE5 inhibitor ku isoko.Intangiriro ya Tmax hamwe nigice cyubuzima nayo iratandukanye mubicuruzwa bya PDE5 byacuruzwa.Sildenafil afite T._maxsaa 1h nigice cyubuzima bwa 3-5 h.Vardenafil isa nkaho na T._maxya 0,6 h nigice cyubuzima bwa 4-6 h.Tadalafil ifite ubuzima burebure burebure mu biyobyabwenge byacurujwe hamwe na kimwe cya kabiri cyubuzima bwa 17 h.ifite intangiriro yihuse yibikorwa igera kuri T._maxmuri 0,6 h hamwe na kimwe cya kabiri cyubuzima bwa 1.2 h.Synthesis ya (TA-1790) isobanurwa mubitabo by'ipatanti.Inzira nyamukuru yo kurandura ni kunyura mu mara no mu mwanda.wasangaga kandi yasubiwemo binyuze muri enterohepatic recirculation.