Cetilistat Cas numero: 282526-98-1 Imiterere ya molekulari ： C25H39NO3
| Ingingo yo gushonga | 72.0 kugeza kuri 76.0 ° C. |
| Ubucucike | 1.02 |
| ububiko bwa temp | Ikidodo cyumye, 2-8 ° C. |
| gukemura | Chloroform (Buhoro), Acetate ya Ethyl (Buhoro) |
| ibikorwa byiza | N / A. |
| Kugaragara | Cryst-yera |
| Isuku | ≥98% |
Cetilistat (izwi kandi ku izina rya ATL-962) yemejwe muri Nzeri 2013 na Minisiteri y’ubuzima, umurimo n’imibereho myiza y’Ubuyapani mu kuvura umubyibuho ukabije, igarukira gusa ku barwayi barwaye diyabete yo mu bwoko bwa 2 (T2DM) na dyslipidemiya, hamwe n’umubiri indangagaciro (BMI) 25 kg / m2nubwo bivura imirire na / cyangwa kuvura imyitozo.Kimwe na orlistat, cetilistat ikora ikoresheje kubuza lipase pancreatic lipase munda kugirango ibuze kwinjiza amavuta bityo bigabanye intungamubiri za caloric ziva mumirire.Porogaramu ya chimie yubuvuzi ntabwo yasobanuwe mubuvanganzo bwa siyansi, ariko ipatanti isobanura cetilistat isobanura kandi guhuza ibigereranyo bifite insimburangingo zitandukanye za aryl hamwe nimirizo ya lipofilique.Synthesis ya cetilistat ikubiyemo guhuza hexadecylcarbonochloridate hamwe na aside-2-amino-5-methylbenzoic;ibindi bigereranyo byashizwemo muguhindura karubone ya karubone na acide 2-aminobenzoic.Cetilistat ninzitizi ikomeye ya lipase yumuntu nimbeba hamwe na IC50sya 15 na 136 nM, kimwe, hamwe no kubuza trypsin cyangwa chymotrypsin.
Inzitizi nshya ya pancreatic lipase inhibitor yo kuvura umubyibuho ukabije haba ku barwayi ba diyabete ndetse n'abarwayi ba diyabete.
Baza Muganga inama mbere
