Umubare wa Cas: 54-31-9 Inzira ya molekulari ： C12H11ClN2O5S
| Ingingo yo gushonga | 261-263 ° C. |
| Ubucucike | 1.16 (igereranya) |
| ububiko bwa temp | Ikirere cyinjiza, Ubushyuhe bwicyumba 2-8 ° C. |
| gukemura | DMSO:> 5 mg / mL kuri 60 ° C. |
| ibikorwa byiza | N / A. |
| Kugaragara | Kuruhande rwera |
| Isuku | ≥98% |
Telmisartan yatangijwe muri Amerika kugirango ivure hypertension.Irashobora gutegurwa mu ntambwe umunani zitangirana na methyl 4-amino-3-methyl benzoate;icyiciro cya mbere n'icya kabiri byizunguruka mu mpeta ya benzimidazole bibaho ku ntambwe ya 4 n'iya 6.Telmisartan ihagarika ibikorwa bya angiotensin II (Ang II), molekile yibanze ya sisitemu ya renin-angiotensin-aldosterone (RAAS).Nubwa gatandatu muri iki cyiciro cya 《sartans》 kugurishwa nyuma yo kuyobora uruganda rwa Losartan.Ingaruka zayo ndende (24h igice cyubuzima) zishobora kuba itandukaniro nyamukuru nabandi barwanya angiotensin II.Bitandukanye nabandi bakozi benshi muriki cyiciro, ibikorwa byayo ntibiterwa no guhinduka metabolite ikora, 1-O-acylglucuronide niyo metabolite nyamukuru iboneka mubantu.Telmisartan ni antagonist ikomeye yo guhangana na reseptor ya AT1 ihuza ingaruka nyinshi zingenzi za angiotensin II mugihe zidafite aho zihurira nubwoko bwa AT2 cyangwa izindi reseptors zigira uruhare mumikorere yumutima.Mu bushakashatsi butandukanye bw’ubuvuzi, Telmisartan, inshuro imwe ya buri munsi, yatanze ingaruka nziza kandi zihoraho zo kugabanya umuvuduko wamaraso hamwe ningaruka nke zingaruka (cyane cyane inkorora ijyanye no kuvura ifitanye isano na inhibitori ya ACE kubarwayi bageze mu zabukuru).
Telmisartan ni angiotensin II reseptor antagonist.
