Umubare numero: 21187-98-4 Inzira ya molekulari
| Ingingo yo gushonga | 163-169 ° C. |
| Ubucucike | 1.2205 (igereranya) |
| ububiko bwa temp | Ikirere cyinjiza, Ubushyuhe bwicyumba 2-8 ° C. |
| gukemura | methylene chloride: gushonga |
| ibikorwa byiza | N / A. |
| Kugaragara | Kuruhande rwera |
| Isuku | ≥98% |
ni imiti yo mu kanwa antihyperglycemic ikoreshwa mu kuvura diyabete mellitus yo mu bwoko bwa II.Ni mubyiciro bya sulfonylurea ya insuline secretagogues, itera β selile ya pancreas kurekura insuline.Ihuza na β selile sulfonyl urea reseptor (SUR1), irusheho guhagarika imiyoboro ya potasiyumu ya ATP.Kubwibyo, potassium efflux iragabanuka cyane, itera depolarisation ya β selile.Noneho imiyoboro ya calcium iterwa na calcium muri β selile irakinguye, bivamo gukora calmoduline, ari nako biganisha kuri exocytose ya insuline irimo granules.Ubushakashatsi buherutse gukorwa bwerekanye kandi ko bushobora kunoza uburyo bwo kurwanya anti-okiside na vasodilasiya ya nitric oxyde-yatewe na diyabete yo mu bwoko bwa 2 kandi bikarinda beta-selile pancreatic beta-selile kwangizwa na hydrogen peroxide.
ni imiti ya hypoglycemic yo mu kanwa ikoreshwa mu kuvura diyabete iterwa na insuline iterwa na insuline. Kuvura diyabete ifitanye isano n'umubyibuho ukabije cyangwa indwara y'amaraso, ku bantu bakuze barwaye diyabete yo mu bwoko bwa 2. Diyabete ni indwara idakira (iramba) igira ingaruka ku buryo umubiri wawe uhinduka ibiryo mu mbaraga.igabanya urugero rwamaraso glucose itera insuline isohoka muri β-selile zo mu birwa bya Langerhans.
