Rifampicin Cas numero: 13292-46-1 Imiterere ya molekulari ： C43H58N4O12
| Ingingo yo gushonga | 183 ° |
| Ubucucike | 1.1782 (igereranya) |
| ububiko bwa temp | 2-8 ° C. |
| gukemura | chloroform: gushonga50mg / mL, birasobanutse |
| ibikorwa byiza | N / A. |
| Kugaragara | umutuku ucyeye kugeza umutuku wijimye cyane |
| Isuku | ≥99% |
Rifampicin ni semisynthetic ikomoka kuri rifamicin B, antibiyotike ya macrolactam na imwe muri antibiyotike zirenga eshanu zivuye mu ruvange rwa rifamicine A, B, C, D, na E, rwitwa rifamicin complex, ikorwa na actinomycetes Streptomyces mediteranei ( Nocardia mediteranei).Yatangijwe mubikorwa byubuvuzi mu 1968. Synthesis ya rifampicin itangirana nigisubizo cyamazi cya rifamicin, mugihe ibintu byifashe neza ihinduka okiside ikomoka kuri rifamicin S (32.7.4), hamwe na rifamicin O (32.7). 3).Kugabanya imiterere ya quinone yiki gicuruzwa hamwe na hydrogen ukoresheje palladium kuri catalizike ya karubone itanga rifamicin SV (32.7.5).Ibicuruzwa bivamo bigira aminomethylation bivanze na fordehide na pyrrolidine, bigatanga 3-pyrrolidinomethylrifamicin SV (32.7.6).Guhindura ibicuruzwa bivamo hamwe na tetracetate ya gurşine kuri enamine hanyuma hydrolysis ikurikiraho hamwe numuti wamazi wa acide acorbike itanga 3-formylrifamicin SV (32.7.7).Kubyitwaramo hamwe na 1-amino-4-methylpiperazine itanga rifampicine yifuza (32.7.8).
Rifampin ikoreshwa nka antibiotique.Nibisobanuro bikomoka kuri rifamycin B, antibiyotike ya macrocyclic yakozwe na mold Streptomyces mediterranei.Rifampin ikoreshwa mu kuvura igituntu, brucellose, Staphlococcus aureus, n'izindi ndwara zanduza.
