Numero ya cas: 144701-48-4 Inzira ya molekulari ： C33H30N4O2
| Ingingo yo gushonga | 261-263 ° C. |
| Ubucucike | 1.16 (igereranya) |
| ububiko bwa temp | Ikirere cyinjiza, Ubushyuhe bwicyumba 2-8 ° C. |
| gukemura | DMSO:> 5 mg / mL kuri 60 ° C. |
| ibikorwa byiza | N / A. |
| Kugaragara | Kuruhande rwera |
| Isuku | ≥98% |
yatangijwe muri Amerika mu kuvura hypertension.Irashobora gutegurwa mu ntambwe umunani zitangirana na methyl 4-amino-3-methyl benzoate;icyiciro cya mbere n'icya kabiri byizunguruka mu mpeta ya benzimidazole bibaho ku ntambwe ya 4 n'iya 6.ihagarika ibikorwa bya angiotensin II (Ang II), molekile yibanze ya molekile ya renin-angiotensin-aldosterone (RAAS).Nubwa gatandatu muri iki cyiciro cya 《sartans》 kugurishwa nyuma yo kuyobora uruganda rwa Losartan.Ingaruka zayo ndende (24h igice cyubuzima) zishobora kuba itandukaniro nyamukuru nabandi barwanya angiotensin II.Bitandukanye nabandi bakozi benshi muriki cyiciro, ibikorwa byayo ntibiterwa no guhinduka muri metabolite ikora, 1-O-acylglucuronide ikaba metabolite nyamukuru iboneka mubantu.ni antagonist ikomeye yo guhatanira kwakirwa na AT1 ihuza ingaruka nyinshi zingenzi za angiotensin II mugihe adafite aho ahurira na AT2 subtypes cyangwa izindi reseptors zigira uruhare mumikorere yumutima.Mu bushakashatsi butandukanye bw’amavuriro, inshuro imwe ya buri munsi, byatanze ingaruka nziza kandi zihoraho zo kugabanya umuvuduko wamaraso hamwe ningaruka nke zingaruka (cyane cyane inkorora ijyanye no kuvura ifitanye isano na ACE inhibitor ku barwayi bageze mu zabukuru).
ni angiotensin II reseptor antagonist.
