Umubare wa Cas: 224785-91-5 Imiterere ya molekulari ： C23H33ClN6O4S Ishusho Yerekanwe

Umubare numero: 224785-91-5 Inzira ya molekulari ： C23H33ClN6O4S

Ibisobanuro bigufi:

Numero ya Cas: 224785-91-5

Izina ryimiti ：

Inzira ya molekulari ：C23H33ClN6O4S

Synonyme ： HCL; Vardenafi; Nuviva; fafinafei; Valdenafil; Levitra, Valdenafil;USP / EP / BP; Levitra, Valdenafil.HCl;224785-91-5;

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Ibicuruzwa birambuye

Ibicuruzwa

Ibicuruzwa byihariye

Ingingo yo gushonga	214-216 ° C.
Ubucucike	N / A.
ububiko bwa temp	Ikirere cyinjiza, 2-8 ° C.
gukemura	N / A.
ibikorwa byiza	N / A.
Kugaragara	Umweru Kuri Off-Yera Cyrstalline
Isuku	≥98%

farumasi

yari umukozi wa kabiri wagurishijwe kandi afite inyungu ko igihe cyayo cyo gutangira kitagabanijwe no gufata imiti munda yuzuye.Ifite imbaraga inshuro 30 nka inhibitori ya PDE5 (bivuze IC50, 3.9 nM) kuruta sildenafil hamwe ninshuro 10 kurenza tadalafil, hamwe no guhitamo gukomeye (> inshuro 1.000) kubantu PDE5 kuruta PDE2, PDE3, na PDE4 na PDE4 na guhitamo mu buryo bushyize mu gaciro (> inshuro 80) kuri PDE1.PDE ibuza guhitamo hamwe na vitro ndetse no muri vivo imbaraga za PDE5 inhibitor.yabujije cyane hydrolysis ya cGMP na PDE5, hamwe na IC50 ya 0.7 nM (sildenafil 6.6 nM).IC50 ya PDE1 yari 180 nM, kuri PDE6 11 nM, no kuri PDE2, PDE3 na PDE4 zirenga 1.000 nM.